General anaesthetic photolabels are used to find the molecular binding sites of anaesthetics, such as GABA receptors, protein kinase and tubulin. Involvement of anaesthetics with voltage-dependent channels for negative ions and the mitochondria has been demonstrated by photolabelling. At clinical concentrations anaesthetics can effect the functioning of proteins. Photolabels can attach to residues or individual molecules lining protein pockets, and thus indicate the presence of a dynamic ligand in a pocket.
Posts Tagged ‘Microtubules’
Halothane binding proteome in human brain cortex :: Roderic Eckenhoff, Maryellen Eckenhoff et al, University of Pennsylvania :: Journal of Proteome Research, 2007, 6, pp. 582-592 :: http://pubs.acs.org/doi/pdf/10.1021/pr060311u Summary and review of the above paper This later study demonstrated that anaesthetics could interact with many human brain proteins; previous studies has been confined to rodent brains. Recent research has expanded rather than contracted the potential targets Read more […]
Inhalational anaesthetic-binding proteins in neuronal membrane Jin Xi, Maryellen Eckenhoff, Roderic Eckenhoff et al, University of Pennsylvania & Amersham Biosciences :: The Journal of Biological Chemistry, Vol. 279, No. 19, May 7 2004, pp. 19628-19633 :: http://www.jbc.org/content/279/19/19628.full.pdf+html Summary and review of the above paper In this study 34 binding sites were identified for the anaesthetic halothane. Within this group, mitochondrial proteins especially those Read more […]
Anaesthetics act in quantum channels in brain microtubules to prevent consciousness Travis Craddock, Stuart Hammerof, Jack Tuszynski et al, Nova Southeastern University, University of Alberta :: www.benthamscience.com/journal/ Summary and review of the above paper INTRODUCTION: Recent research into the binding of anaesthetic molecules looks to revive the idea of hydrophobic pockets in the microtubules of neurons as the most suitable binding site for anaesthetic molecules. This could Read more […]
Achilles’ heels of the Orch OR model NeuroQuantology, March 2007, Vol 5, Issue 1, pp. 182-5 www.neuroquantology.com/ Summary and review of the above paperin fact Every new entrant to consciousness studies has to prove their worth by refuting Penrose, although this is often at the expense of reducing their own credibility. The core argument in this paper is that when a subjective experience involves a perception that is untrue, such that something belongs to you when it belongs to someone Read more […]
The feasibility of coherent energy transfer in microtubules Travis Craddock et al, Nova Southeastern University http://arxiv.org/abs/1405.3170 Summary and review of the above paper INTRODUCTION: Craddock’s paper emphasises the strong similarities between tryptophan complexes in microtubules and quantum coherent energy transfer in photosynthesis, a connection which is dumbed out in most discussions of quantum biology. The microtubules are themselves closely connected to mitochondria; Read more […]
Atomic water channel controlling remarkable properties of a single brain microtubule: Correlating single protein to its supramolecular assembly Satyajit Sahu & Anirban Bandyopadhyay et al, National Institute for Materials Science, Japan Biosensors and Bioelectronics 47 141-148, 21 February 2013 Summary and review of the above paper INTRODUCTION: The authors say the prior to this paper the properties of tubulin and microtubules were not extensively studies using the up-to-date technologies Read more […]