Posts Tagged ‘anaesthetic ligands’

Mechanisms of anaesthesia

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General anaesthetic photolabels are used to find the molecular binding sites of anaesthetics, such as GABA receptors, protein kinase and tubulin. Involvement of anaesthetics with voltage-dependent channels for negative ions and the mitochondria has been demonstrated by photolabelling. At clinical concentrations anaesthetics can effect the functioning of proteins. Photolabels can attach to residues or individual molecules lining protein pockets, and thus indicate the presence of a dynamic ligand in a pocket.